Neurobiology of Disease Shift from Extracellular Signal-Regulated Kinase to AKT/ cAMP Response Element-Binding Protein Pathway Increases Survival-Motor-Neuron Expression in Spinal-Muscular- Atrophy-Like Mice and Patient Cells
نویسندگان
چکیده
Julien Branchu,1 Olivier Biondi,1 Farah Chali,1 Thibault Collin,2 Felix Leroy,3 Kamel Mamchaoui,4 Joelle Makoukji,1 Claude Pariset,1 Philippe Lopes,1,5 Charbel Massaad,1 Christophe Chanoine,1 and Frédéric Charbonnier1 1Centre d’Étude de la Sensorimotricité, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8194, 2Laboratoire de Physiologie Cérébrale, CNRS UMR 8118, and 3Neurophysique et Physiologie du Système Moteur, CNRS UMR 8119, Université Paris Descartes, Unité de Formation et de Recherche Biomédicale, F-75270 Paris, France, 4Thérapie des Maladies du Muscle Strié/Institut de Myologie, Unité Mixte de Recherche en Santé 974 –Université Pierre et Marie Curie, Université Paris 6/Institut National de la Santé et de la Recherche Médicale Unité 974/CNRS UMR 7215, Groupe Hospitalier Pitié-Salpêtrière–Bâtiment Babinski, F-75651 Paris, France, and 5Université d’Evry-val-d’Essonne, F-91000 Evry, France
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